Taxol Analysis
Paclitaxel (Taxol) and some taxane analogs have shown distinct promise as anti-cancer and anti-tumor drugs. The big demand for taxanes for clinical use has led to intense study of their production, isolation, purification, and partial or total synthesis.

Chromatographic methods have been developed to detect and isolate taxanes on an analytical and preparative scale.  A number of studies of the high performance liquid chromatography separation of taxanes have also emerged.

With the expanding interest in taxol and other taxoids for treatment of breast and ovarian cancers, MetaChem offers three HPLC columns which provide excellent resolution of essentially all taxoids .Taxsil™ columns offer excellent resolving power for taxol and its related compounds using simple MeOH: Water eluents. Taxsil-2 and Taxsil-3 columns offer alternative selectivities to the original Taxsil™ columns. These new phases offer improved resolution of 10-deacetyltaxol and 7-xylosyltaxol.  Taxsil-2 has the interesting property of being able to resolve most of the common taxoids using either gradient elution or isocratic elution.